DNA GYRASE INHIBITORY AND ANTIBACTERIAL ACTIVITY OF SOME FLAVONES (1)

被引：164

作者：

OHEMENG, KA

SCHWENDER, CF

FU, KP

BARRETT, JF

机构：

[1] The R.W. Johnson Pharmaceutical Research Institute Raritan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80881-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of flavones was studied for their DNA-gyrase inhibitory and antibacterial activities. This led to the identification of compounds with potent Escherichia coli DNA-gyrase inhibitory activity, and modest antimicrobial activity. The most active compound, ellagic acid has an IC50 = 3.3 mug/ml, which is comparable to some of the currently marketed 4-quinolone antibacterials.

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页码：225 / 230

页数：6

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