ACROLEIN GENOTOXICITY IN DROSOPHILA-MELANOGASTER .3. EFFECTS OF METABOLISM MODIFICATION

被引：5

作者：

BARROS, AR ^{[1
]}

SIERRA, LM ^{[1
]}

COMENDADOR, MA ^{[1
]}

机构：

[1] UNIV OVIEDO,DEPT BIOL FUNC,AREA GENET,E-33071 OVIEDO,SPAIN

来源：

MUTATION RESEARCH | 1994年 / 321卷 / 03期

关键词：

ACROLEIN; DROSOPHILA MELANOGASTER; METABOLISM MODIFICATION; SEX-LINKED RECESSIVE LETHAL TEST;

D O I：

10.1016/0165-1218(94)90035-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In order to investigate the role of metabolism in acrolein genotoxicity in D. melanogaster, the action of several metabolism modifiers, namely phenobarbital, an inducer of xenobiotic metabolism, phenylimidazole and iproniazid, inhibitors of oxidative activities of cytochrome P450, and diethyl maleate, a glutathione-depleting agent, have been assayed using the sex-linked recessive lethal (SLRL) test, with two different administration routes (feeding and injection). The results support the hypothesis that acrolein is not only a direct mutagen but is also transformed, by oxidative activities of cytochrome P450 after glutathione conjugation, into an active metabolite, possibly glycidaldehyde. Moreover, acrolein is deactivated by an enzymatic activity induced by phenobarbital.

引用

页码：119 / 126

页数：8

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