CYTOGENETIC EFFECTS OF RIFAMPICIN IN SOMATIC AND GERMINAL CELLS OF THE MOUSE

被引：9

作者：

ABOULELA, EI

机构：

[1] Genetics and Cytology Dept, National Research Centre, Cairo, Dokki

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1995年 / 15卷 / 04期

关键词：

RIFAMPICIN; GENOTOXICITY; CHROMOSOMAL ABERRATION;

D O I：

10.1002/jat.2550150415

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The genotoxicity of rifampicin was tested for sister chromatic exchange in bone marrow cells and for structural chromosomal aberrations in mouse germ cells. Sister chromatid exchange frequency increased after 160, 240 and 310 mg kg(-1) body wt. doses but not after 80 mg kg(-1). In spermatocytes, 80 mg kg(-1) rifampicin increased the frequency of chromosomal aberrations from the 3.5% control level to 14% after 1 day and 34.5% after 7 days.

引用

页码：325 / 326

页数：2

共 7 条

[1]

ALLEN JW, 1982, METHOD CONDUCTING SC

[2]

BYWATER RJ, 1982, VETER APPL PHARM THE, P456

[3] AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES [J].

EVANS, EP ;

BRECKON, G ;

FORD, CE .

CYTOGENETICS, 1964, 3 (05) :289-&

[4]

HARVEY SC, 1990, REMINGTONS PHARM SCK, P1155

[5]

Paget GE., 1964, PHARMACOMETRICS, P161

[6] NEW GIEMSA METHOD FOR DIFFERENTIAL STAINING OF SISTER CHROMATIDS [J].

PERRY, P ;

WOLFF, S .

NATURE, 1974, 251 (5471) :156-158

[7]

SIMON C, 1985, ANTIBIOTIC THERAPY C, P235

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