EFFECT OF CRYSTALLIZATION OF THEOPHYLLINE ON PHYSICAL-PROPERTIES OF TABLETS

被引：8

作者：

ANDO, H

ISHII, M

KAYANO, M

WATANABE, S

机构：

[1] Pharmaceutical Development Research Laboratories, Eisai Co., Ltd., Tsukuba-shi, Ibaraki, 300-26, 1-3,r Tokodai Scheme

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 19期

关键词：

D O I：

10.3109/03639049509065903

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Tablets containing anhydrous theophylline, a hygroscopic material such as magnesium chloride or potassium acetate, and other constituents were stored for 4 and 12 weeks under 90% relative humidity at 37 degrees C. During storage, whisker-like crystals appeared on the surface of the tablets. The crystals were observed under a scanning electron microscope. Changes were found in the physical properties of these tablets: crushing strength, friability, disintegration time and dissolution rate.

引用

页码：2227 / 2237

页数：11

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