METHOTREXATE ANALOGS .17. ANTITUMOR-ACTIVITY OF 4-AMINO-4-DEOXY-N10-METHYLPTEROYL-D,L-HOMOCYSTEIC ACID AND ITS DUAL INHIBITION OF DIHYDROFOLATE-REDUCTASE AND FOLYL POLYGLUTAMATE SYNTHETASE

被引:23
作者
ROSOWSKY, A
MORAN, RG
FORSCH, R
COLMAN, P
UREN, J
WICK, M
机构
[1] CHILDRENS HOSP LOS ANGELES,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
D O I
10.1016/0006-2952(84)90383-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:155 / 161
页数:7
相关论文
共 49 条
[1]  
ARONS E, 1975, CANCER RES, V35, P2033
[2]  
BADINSKA M, 1981, CANCER RES, V41, P2751
[3]   FOLYLPOLY-GAMMA-GLUTAMATES AS CO-SUBSTRATES OF 10-FORMYLTETRAHYDROFOLATE-5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLE-CARBOXAMIDE FORMYLTRANSFERASE [J].
BAGGOTT, JE ;
KRUMDIECK, CL .
BIOCHEMISTRY, 1979, 18 (06) :1036-1041
[4]   POLYGAMMAGLUTAMYL METABOLITES OF METHOTREXATE [J].
BAUGH, CM ;
KRUMDIECK, CL ;
NAIR, MG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 52 (01) :27-34
[5]   SPECIFICITY OF FOLIATE-GAMMA-L-GLUTAMATE LIGASE IN RAT-LIVER AND KIDNEY - BIOSYNTHESIS OF POLY-GAMMA-L-GLUTAMATES OF UNREDUCED METHOTREXATE AND EFFECT OF METHOTREXATE ON FOLATE POLYGLUTAMATE BIOSYNTHESIS [J].
BROWN, JP ;
DAVIDSON, GE ;
WEIR, DG ;
SCOTT, JM .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1974, 5 (9-10) :727-733
[6]   FOLYLPOLY-GAMMA-GLUTAMATE SYNTHESIS BY BACTERIA AND MAMMALIAN-CELLS [J].
CICHOWICZ, DJ ;
FOO, SK ;
SHANE, B .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1981, 39 (SEP) :209-228
[7]  
CLELAND WW, 1967, ADV ENZYMOL RAMB, V29, P1
[8]   5-METHYL-5,6,7,8-TETRAHYDROPTEROYL OLIGO-GAMMA-L-GLUTAMATES - SYNTHESIS AND KINETIC STUDIES WITH METHIONINE SYNTHETASE FROM BOVINE BRAIN [J].
COWARD, JK ;
CHELLO, PL ;
CASHMORE, AR ;
PARAMESWARAN, KN ;
DEANGELIS, LM ;
BERTINO, JR .
BIOCHEMISTRY, 1975, 14 (07) :1548-1552
[9]   7,8-DIHYDROPTEROYL OLIGO-GAMMA-L-GLUTAMATES - SYNTHESIS AND KINETIC STUDIES WITH PURIFIED DIHYDROFOLATE-REDUCTASE FROM MAMMALIAN SOURCES [J].
COWARD, JK ;
PARAMESWARAN, KN ;
CASHMORE, AR ;
BERTINO, JR .
BIOCHEMISTRY, 1974, 13 (19) :3899-3903
[10]  
COWARD JK, 1979, DRUG ACTION DESIGN M, P17