AN EFFICIENT SYNTHESIS OF PLATELET-ACTIVATING FACTOR (PAF) VIA 1-0-ALKYL-2-O-(3-ISOXAZOLYL)-SN-GLYCERO-3-PHOSPHOCHOLINE, A NEW PAF AGONIST - UTILIZATION OF THE 3-ISOXAZOLYLOXY GROUP AS A PROTECTED HYDROXYL

被引：13

作者：

NAKAMURA, N ^{[1
]}

MIYAZAKI, H ^{[1
]}

OHKAWA, N ^{[1
]}

OSHIMA, T ^{[1
]}

KOIKE, H ^{[1
]}

机构：

[1] SANKYO CO LTD,BIOL RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)94606-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Potent PAF agonists (R)-3a,b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy group into the inverted alcohol. © 1990.

引用

页码：699 / 702

页数：4

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