THE CONFORMATION OF 6-METHOXYERYTHROMYCIN-A IN WATER DETERMINED BY PROTON NMR-SPECTROSCOPY

被引：23

作者：

STEINMETZ, WE ^{[1
]}

BERSCH, R ^{[1
]}

TOWSON, J ^{[1
]}

PESIRI, D ^{[1
]}

机构：

[1] GLENDORA HIGH SCH,GLENDORA,CA 91740

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 26期

关键词：

D O I：

10.1021/jm00104a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The proton NMR spectrum of an aqueous solution of 6-methoxyerythromycin A (2) has been assigned and nuclear Overhauser effects have been obtained from a series of NOESY spectra Carbon-13 antisymmetric spin-lattice relaxation times have been measured for the methylene and methine carbons. The NMR data show that 2 is present exclusively in the keto form and has a conformation very similar to that reported for erythromycin A (1) in the solid and solution phases.

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页码：4842 / 4845

页数：4

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