THE AREA OF 2-[I-125]IODOMELATONIN BINDING IN THE PARS TUBERALIS OF THE GROUND-SQUIRREL IS DECREASED DURING HIBERNATION

被引：31

作者：

STANTON, TL

SIUCIAK, JA

DUBOCOVICH, ML

KRAUSE, DN

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT PHARMACOL,CHICAGO,IL 60611

[2] UNIV CALIF IRVINE,CALIF COLL MED,DEPT PHARMACOL,IRVINE,CA 92717

来源：

BRAIN RESEARCH | 1991年 / 557卷 / 1-2期

关键词：

MELATONIN; 2-[I-125]IODOMELATONIN BINDING; GROUND SQUIRREL; HIBERNATION; PARS TUBERALIS; RECEPTOR AUTORADIOGRAPHY;

D O I：

10.1016/0006-8993(91)90145-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Quantitative receptor autoradiography was used to analyze 2-[I-125]iodomelatonin binding sites in the brains of golden-mantled ground squirrels (Citellus lateralis). Specific binding appeared to be discretely localized to the pars tuberalis region of the pituitary that surrounds the medial basal hypothalamus. The total area of binding was significantly decreased in brains of hibernating squirrels as compared to those of awake, euthermic animals. These findings support a role for melatonin receptors of the pars tuberalis in seasonal behavior.

引用

页码：285 / 288

页数：4

共 17 条

[1]

BECKMAN AL, 1982, NEURAL BASIS BEHAV, P19

[2] MELATONIN BINDING-SITES IN THE SHEEP PARS TUBERALIS [J].