GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC DETERMINATION OF ISOSORBIDE 5-MONONITRATE IN HUMAN PLASMA

被引：14

作者：

LAUROMARTY, C

LARTIGUEMATTEI, C

CHABARD, JL

BEYSSAC, E

AIACHE, JM

MADESCLAIRE, M

机构：

[1] FAC PHARM CLERMONT FERRAND,CHIM ANAL & SPECTROMETRIE MASSE LAB,RECH BIODYNAM MED GRP,F-63001 CLERMONT FERRAND,FRANCE

[2] FAC PHARM CLERMONT FERRAND,BIOPHARM LAB,RECH BIODYNAM MED GRP,F-63001 CLERMONT FERRAND,FRANCE

[3] FAC PHARM CLERMONT FERRAND,CHIM THERAPEUT LAB,F-63001 CLERMONT FERRAND,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 663卷 / 01期

关键词：

D O I：

10.1016/0378-4347(94)00436-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A highly specific and precise method using gas chromatography-mass spectrometry was developed for the measurement of isosorbide 5-mononitrate in plasma using isomannide mononitrate as internal standard. With regard to the numerous analytical problems encountered when organic mononitrates were determined in plasma, such as thermal instability and adsorption, compounds were silylated before gas chromatography. In order to increase the specificity of the assay, two specific ions of the isosorbide 5-monitrate were simultaneously recorded. The accuracy of the assay was tested day to day with quality specimens spiked blind to the analyst.

引用

页码：153 / 159

页数：7

共 8 条

[1]

ABSHAGEN U, 1985, MONONITRATES, P3

[2] QUANTITATIVE MEASUREMENT OF CLENBUTEROL AT THE FEMTOMOLE LEVEL IN PLASMA AND URINE BY COMBINED GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

GIRAULT, J ;

GOBIN, P ;

FOURTILLAN, JB .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1990, 19 (02) :80-88

[3] THE ACTION OF PYRIDINE ON THE DINITRATE ESTERS OF 1,4-3,6-DIANHYDROHEXITOLS [J].

JACKSON, M ;

HAYWARD, LD .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1960, 38 (04) :496-502

[4] CLINICAL CHRONOPHARMACOLOGY OF ORAL SUSTAINED-RELEASE ISOSORBIDE-5-MONONITRATE IN HEALTHY-SUBJECTS [J].

LEMMER, B ;

SCHEIDEL, B ;

BLUME, H ;

BECKER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 40 (01) :71-75

[5] GAS-LIQUID-CHROMATOGRAPHIC DETERMINATION OF ISOSORBIDE-5-MONONITRATE DERIVATIZED WITH PERFLUORINATED ANHYDRIDES FOR PHARMACOKINETIC AND BIOAVAILABILITY INVESTIGATIONS [J].

MARZO, A ;

TREFFNER, E .

JOURNAL OF CHROMATOGRAPHY, 1985, 345 (02) :390-395

[6] DETERMINATION OF ISOSORBIDE 5-MONONITRATE IN HUMAN-PLASMA BY CAPILLARY COLUMN GAS-CHROMATOGRAPHY [J].

STRAEHL, P ;

GALEAZZI, RL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (09) :1317-1319

[7] GAS-CHROMATOGRAPHIC ANALYSIS OF ISOMERIC ORGANIC MONONITRATES IN PLASMA [J].

TZENG, TB ;

FUNG, HL .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 571 (1-2) :109-120

[8] DETERMINATION OF ISOSORBIDE-5-MONONITRATE IN HUMAN SERUM BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

ZUCCARO, P ;

ZUCCARO, SM ;

PACIFICI, R ;

PICHINI, S ;

BONIFORTI, L .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (02) :447-453

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