LEUKOTRIENE-B4 RELEASE AND POLYMORPHONUCLEAR CELL INFILTRATION IN SPINAL-CORD INJURY

被引:104
作者
XU, J
HSU, CY
LIU, TH
HOGAN, EL
PEROT, PL
TAI, HH
机构
[1] MED UNIV S CAROLINA, DEPT NEUROL, 171 ASHLEY AVE, CHARLESTON, SC 29425 USA
[2] UNIV KENTUCKY, COLL PHARM, LEXINGTON, KY 40506 USA
[3] MED UNIV S CAROLINA, DEPT NEUROSURG, CHARLESTON, SC 29425 USA
[4] BAYLOR UNIV, DIV RESTORAT NEUROL, HOUSTON, TX 77030 USA
关键词
Arachidonic acid; Myeloperoxidase; Radioimmunoassay;
D O I
10.1111/j.1471-4159.1990.tb04577.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Abstract: Activation of arachidonic acid occurs after spinal cord injury. Leukotriene B4 is a lipoxygenase metabolite of arachidonic acid. In a rat model of experimental spinal cord injury, we found that the leukotriene B4 content was less than the sensitivity of our assay (8 pg/mg of protein) in non‐traumatized spinal cord. Leukotriene B4 was detectable in raumatized cord (mean ± SE, 25 ± 5 pg/mg of protein; n = 3). Release of leukotriene B4 from spinal cord slices into the incubation medium was also noted after trauma (9 ± 1 pg/mg of protein; n = 12) and was enhanced by exposure of traumatized spinal cord slices to the calcium ionophore A23187 (375 ± 43 pg/mg of protein; n = 12). The amount of leukotriene B4 released corresponded to the extent of post‐traumatic polymorphonuclear cell infiltration determined by a myeloperoxidase assay. Results from this study suggest that the source of leukotriene B4 in spinal cord injury is infiltrating polymorphonuclear cells. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:907 / 912
页数:6
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