DIETARY EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID FROM FISH OIL - THEIR INCORPORATION INTO ADVANCED HUMAN ATHEROSCLEROTIC PLAQUES

被引:59
作者
RAPP, JH
CONNOR, WE
LIN, DS
PORTER, JM
机构
[1] OREGON HLTH SCI UNIV,DEPT MED,CLIN NUTR & LIPID METAB,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT SURG,DIV VASC SURG,PORTLAND,OR 97201
来源
ARTERIOSCLEROSIS AND THROMBOSIS | 1991年 / 11卷 / 04期
关键词
HUMAN ATHEROSCLEROSIS; DIETARY LIPIDS; OMEGA-3 FATTY ACIDS;
D O I
10.1161/01.ATV.11.4.903
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The incorporation of fatty acids from dietary fish oil was measured in obstructive atherosclerotic plaques removed from 11 patients fed fish oil, rich in omega-3 fatty acids, for 6-120 days before a planned arterial endarterectomy. The fatty acids of plasma and atheroma were analyzed with special reference to docosahexaenoic acid (DHA, 22:6) and eicosapentaenoic acid (EPA, 20:5), the principal omega-3 fatty acids of fish oil. The omega-3 fatty acid content increased greatly in plasma from 0.9% of fatty acids to 14.8% in cholesteryl esters, from 3.8% to 22.1% in phospholipids, and from 1.3% to 21.9% in triglycerides. The omega-3 fatty acid content of the atherosclerotic plaques was also greater when compared with that of plaques removed from 18 non-fish oil-fed controls. The omega-3 fatty acid in cholesteryl esters of the plaques was 4.9% in the experimental group versus 1.4% in control plaque, in phospholipids it was 8.8% versus 1.8%, and in triglycerides it was 4.7% versus 0.7% (p < 0.001 for each lipid class). The two major omega-3 fatty acids (DHA and EPA) behaved differently. Compared with their respective plasma levels, relatively more DHA than EPA was deposited into the plaques. Whereas the increase of omega-3 fatty acids in plasma reached a plateau 3 weeks after initiation of fish oil feeding, a linear increase in plaque omega-3 fatty acids continued with time. As a result of the changes in fatty acid composition, the lipid classes of both plasma and plaque had a higher unsaturation index in the fish oil-fed group. Our data demonstrate that dietary omega-3 fatty acids are readily incorporated into advanced human atherosclerotic plaques. Changes in the fatty acids of plasma lipids are reflected in substantial changes in the plaque fatty acid content over a relatively short time. Because omega-3 fatty acids affect so many factors predisposing to both thrombosis and atherosclerosis, these data may have clinical implications.
引用
收藏
页码:903 / 911
页数:9
相关论文
共 35 条
[1]  
BROMSGUSTSCHONT.HC, 1981, AM J CLIN NUTR, V34, P1752
[2]  
BURR ML, 1989, LANCET, V2, P757
[3]   INHIBITION OF VEIN GRAFT INTIMAL THICKENING BY EICOSAPENTANOIC ACID - REDUCED THROMBOXANE PRODUCTION WITHOUT CHANGE IN LIPOPROTEIN LEVELS OR LOW-DENSITY LIPOPROTEIN RECEPTOR DENSITY [J].
CAHILL, PD ;
SARRIS, GE ;
COOPER, AD ;
WOOD, PD ;
KOSEK, JC ;
MITCHELL, RS ;
MILLER, DC .
JOURNAL OF VASCULAR SURGERY, 1988, 7 (01) :108-118
[4]   FISH OIL INHIBITS DEVELOPMENT OF ATHEROSCLEROSIS IN RHESUS-MONKEYS [J].
DAVIS, HR ;
BRIDENSTINE, RT ;
VESSELINOVITCH, D ;
WISSLER, RW .
ARTERIOSCLEROSIS, 1987, 7 (05) :441-449
[5]   REDUCTION IN THE RATE OF EARLY RESTENOSIS AFTER CORONARY ANGIOPLASTY BY A DIET SUPPLEMENTED WITH N-3 FATTY-ACIDS [J].
DEHMER, GJ ;
POPMA, JJ ;
VANDENBERG, EK ;
EICHHORN, EJ ;
PREWITT, JB ;
CAMPBELL, WB ;
JENNINGS, L ;
WILLERSON, JT ;
SCHMITZ, JM .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (12) :733-740
[6]   EFFECTS OF DIETARY FISH OIL SUPPLEMENTATION ON POLYMORPHONUCLEAR LEUKOCYTE INFLAMMATORY POTENTIAL [J].
FISHER, M ;
UPCHURCH, KS ;
LEVINE, PH ;
JOHNSON, MH ;
VAUDREUIL, CH ;
NATALE, A ;
HOOGASIAN, JJ .
INFLAMMATION, 1986, 10 (04) :387-392
[7]   MALONDIALDEHYDE ALTERATION OF LOW-DENSITY LIPOPROTEINS LEADS TO CHOLESTERYL ESTER ACCUMULATION IN HUMAN MONOCYTE-MACROPHAGES [J].
FOGELMAN, AM ;
SHECHTER, I ;
SEAGER, J ;
HOKOM, M ;
CHILD, JS ;
EDWARDS, PA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2214-2218
[8]  
FOLCH J, 1957, J BIOL CHEM, V226, P497
[9]   FISH OILS INHIBIT ENDOTHELIAL-CELL PRODUCTION OF PLATELET-DERIVED GROWTH-FACTOR LIKE PROTEIN [J].
FOX, PL ;
DICORLETO, PE .
SCIENCE, 1988, 241 (4864) :453-456
[10]   POLY-UNSATURATED FATTY-ACIDS, HYPERLIPIDEMIA, AND THROMBOSIS [J].
GOODNIGHT, SH ;
HARRIS, WS ;
CONNOR, WE ;
ILLINGWORTH, DR .
ARTERIOSCLEROSIS, 1982, 2 (02) :87-113