AN EFFICIENT PROCEDURE FOR THE REGIOSELECTIVE MONOPROTECTION OF 1,2-DIOLS

被引：14

作者：

BARTON, DHR

ZHU, JP

机构：

[1] Department of Chemistry, Texas A and M University, College Station

来源：

TETRAHEDRON | 1992年 / 48卷 / 39期

关键词：

1,2-DIOLS; ISOPROPYLIDENE KETALS; CARBOHYDRATES; TRIMETHYLALUMINUM; REGIOSELECTIVITY;

D O I：

10.1016/S0040-4020(01)86582-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic ring opening of isopropylidene ketals by trimethylaluminum is described. This reagent offers a new method for selective monoprotection of 1,2-diols. The regioselectivity of this reaction was studied with simple diols and with carbohydrates.

引用

收藏

页码：8337 / 8346

页数：10

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