COMPARISON OF THE EFFECTS OF SEVOFLURANE, ISOFLURANE AND HALOTHANE ON INDOCYANINE GREEN CLEARANCE

被引:35
作者
KANAYA, N
NAKAYAMA, M
FUJITA, S
NAMIKI, A
机构
[1] Department of Anesthesiology, School of Medicine, Sapporo Med. University, S-1, W-16, Chuo-ku
关键词
ANESTHETICS VOLATILE; SEVOFLURANE; ISOFLURANE; HALOTHANE; LIVER; BLOOD FLOW;
D O I
10.1093/bja/74.2.164
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We have examined the effects of inhalation anaesthetics on indocyanine green (ICG) clearance, as an index of hepatic function, in patients undergoing elective surgery. Recently, a new method has been developed to measure in real-time the disappearance rate of ICG from plasma. This method eliminates the multiple sampling and delay of the conventional ICG test. ICG clearance is displayed as two indices: K (ICG disappearance rate) and R(15) (ICG retention rate 15 min after injection of ICG 0.5 mg kg(-1)). This measurement was performed in patients before and after 1 MAC of sevoflurane (n = 6), 2 MAC of sevoflurane (n = 6), 1 MAC of isoflurane (n = 6), 2 MAC of isoflurane (n = 6), 1 MAC of halothane (n = 6) or 2 MAC of halothane (n = 6) without surgical stress. Although mean arterial pressure decreased significantly at 1 and 2 MAC of sevoflurane, 2 MAC of halothane, and 1 and 2 MAC of isoflurane, ICG clearance was maintained at awake levels, except at 2 MAC of halothane (K = mean-33 (SEM 3)%, R(15) = +90 (3)% from awake values). We conclude that sevoflurane and isoflurane have a more favourable effect on liver circulation than halothane.
引用
收藏
页码:164 / 167
页数:4
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