P-TYPE ATPASE FROM THE CYANOBACTERIUM SYNECHOCOCCUS-7942 RELATED TO THE HUMAN MENKES AND WILSON DISEASE GENE-PRODUCTS

被引：95

作者：

PHUNG, LT ^{[1
]}

AJLANI, G ^{[1
]}

HASELKORN, R ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 20期

关键词：

D O I：

10.1073/pnas.91.20.9651

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA encoding a P-type ATPase was cloned from the cyanobacterium Synechococcus 7942. The cloned ctaA gene encodes a 790-amino acid polypeptide related to the CopA Cu2+-uptake ATPase of Enterococcus hirae, to other known P-type ATPases, and to the candidate gene products for the human diseases of copper metabolism, Menkes disease and Wilson disease. Disruption of the single chromosomal gene in Synechococcus 7942 by insertion of an antibiotic-resistance cassette results in a mutant cell line with increased tolerance to CU2+ compared with the wild type.

引用

页码：9651 / 9654

页数：4

共 31 条

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