USE OF SUPPRESSOR ANALYSIS TO IDENTIFY DNA-POLYMERASE MUTATIONS IN HERPES-SIMPLEX VIRUS WHICH AFFECT DEOXYNUCLEOSIDE TRIPHOSPHATE SUBSTRATE-SPECIFICITY

被引：22

作者：

WANG, Y ^{[1
]}

WOODWARD, S ^{[1
]}

HALL, JD ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT MOLEC & CELLULAR BIOL,TUCSON,AZ 85721

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期

关键词：

D O I：

10.1128/JVI.66.3.1814-1816.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus DNA polymerase mutations which map in the N-terminal part of the protein and appear to alter deoxynucleoside triphosphate (dNTP) substrate specificity are described. These mutations suppress a drug hypersensitivity associated with the downstream mutation, Aph(r)10. We suggest that the mutant residues form part of the dNTP-binding site, a site previously thought to be confined to the C terminus.

引用

页码：1814 / 1816

页数：3

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