DEFICIENCY OF FIBRINOLYTIC ENZYME-ACTIVITIES IN THE SERUM OF PATIENTS WITH ALZHEIMER-TYPE DEMENTIA

被引：22

作者：

AOYAGI, T

WADA, T

KOJIMA, F

NAGAI, M

HARADA, S

TAKEUCHI, T

ISSE, K

OGURA, M

HAMAMOTO, M

TANAKA, K

NAGAO, T

机构：

[1] SHOWA COLL PHARMACEUT SCI,TOKYO 194,JAPAN

[2] TOKYO METROPOLITAN JAMA GERIATR HOSP,TOKYO 187,JAPAN

来源：

EXPERIENTIA | 1992年 / 48卷 / 07期

关键词：

ALZHEIMERS DISEASE; PATIENTS SERUM; CLOTTING SYSTEM; FIBRINOLYTIC SYSTEM; PLASMIN; UROKINASE; THROMBIN;

D O I：

10.1007/BF02118312

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients.

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页码：656 / 659

页数：4

相关论文

共 29 条

[1] VARIOUS ENZYME-ACTIVITIES IN MUSCLE AND OTHER ORGANS OF DYSTROPHIC MICE [J].

AOYAGI, T ;

WADA, T ;

KOJIMA, F ;

NAGAI, M ;

UMEZAWA, H .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (01) :51-59

[2] DEFICIENCY OF KALLIKREIN-LIKE ENZYME-ACTIVITIES IN CEREBRAL TISSUE OF PATIENTS WITH ALZHEIMERS-DISEASE [J].

AOYAGI, T ;

WADA, T ;

NAGAI, M ;

KOJIMA, F ;

HARADA, S ;

TAKEUCHI, T ;

TAKAHASHI, H ;

HIROKAWA, K ;

TSUMITA, T .

EXPERIENTIA, 1990, 46 (01) :94-97

[3] ALTERED LYMPHOCYTE ACETYLCHOLINESTERASE ACTIVITY IN PATIENTS WITH SENILE DEMENTIA [J].

BARTHA, E ;

SZELENYI, J ;

SZILAGYI, K ;

VENTER, V ;

HA, NTT ;

PALDIHARIS, P ;

HOLLAN, S .

NEUROSCIENCE LETTERS, 1987, 79 (1-2) :190-194

[4] ALZHEIMERS-DISEASE - A METABOLIC SYSTEMS DEGENERATION [J].

BLASS, JP ;

ZEMCOV, A .

NEUROCHEMICAL PATHOLOGY, 1984, 2 (02) :103-114

[5] STIMULATED PLATELETS RELEASE AMYLOID BETA-PROTEIN PRECURSOR [J].

COLE, GM ;

GALASKO, D ;

SHAPIRO, IP ;

SAITOH, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 170 (01) :288-295

[6] RAPID AND SIMPLE SPECTROPHOTOMETRIC ASSAY OF ANGIOTENSIN-CONVERTING ENZYME [J].

HAYAKARI, M ;

KONDO, Y ;

IZUMI, H .

ANALYTICAL BIOCHEMISTRY, 1978, 84 (02) :361-369

[7] PHOSPHORYLATED TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS IN ALZHEIMERS-DISEASE [J].

IHARA, Y ;

NUKINA, N ;

MIURA, R ;

OGAWARA, M .

JOURNAL OF BIOCHEMISTRY, 1986, 99 (06) :1807-1810

[8] INHIBITORS OF LYSOSOMAL-ENZYMES - ACCUMULATION OF LIPOFUSCIN-LIKE DENSE BODIES IN THE BRAIN [J].

IVY, GO ;

SCHOTTLER, F ;

WENZEL, J ;

BAUDRY, M ;

LYNCH, G .

SCIENCE, 1984, 226 (4677) :985-987

[9] HIGHLY SENSITIVE PEPTIDE-4-METHYLCOUMARYL-7-AMIDE SUBSTRATES FOR BLOOD-CLOTTING PROTEASES AND TRYPSIN [J].

KAWABATA, SI ;

MIURA, T ;

MORITA, T ;

KATO, H ;

FUJIKAWA, K ;

IWANAGA, S ;

TAKADA, K ;

KIMURA, T ;

SAKAKIBARA, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (01) :17-25

[10] DEFICIENCY OF A CHOLINERGIC DIFFERENTIATING FACTOR IN FIBROBLASTS OF PATIENTS WITH ALZHEIMERS-DISEASE [J].

KESSLER, JA .

ANNALS OF NEUROLOGY, 1987, 21 (01) :95-98