DRUG-INTERACTION BETWEEN RIFAMPICIN, ISONIAZID AND COTRIMOXAZOLE IN RABBITS

被引：2

作者：

MALHI, R ^{[1
]}

UPPAL, R ^{[1
]}

SHARMA, PL ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT PHARMACOL,CHANDIGARH 160012,INDIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1992年 / 11卷 / 02期

关键词：

D O I：

10.1177/096032719201100208

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 The results of cotrimoxazole (CTZ) co-administration (15 mg kg-1 trimethoprim + 40 mg kg-1 sulphamethoxazole) on plasma concentration and various pharmacokinetic parameters of rifampicin (RIF, 24 mg kg-1) and isoniazid (INH, 14 mg kg-1) were studied. 2 In the test group (n = 6), CTZ was administered on the 24th day of antitubercular treatment (ATT) and given for 7 d. 3 At the end of concurrent treatment with CTZ, RIF half-life (t1/2) and plasma concentration were both increased. However, there was no effect on INH half-life and plasma concentration.

引用

页码：105 / 107

页数：3

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