GENE INHIBITION USING ANTISENSE OLIGODEOXYNUCLEOTIDES

被引：793

作者：

WAGNER, RW

机构：

[1] Gilead Sciences, Foster City, CA 94404

来源：

NATURE | 1994年 / 372卷 / 6504期

关键词：

D O I：

10.1038/372333a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specific gene inhibition. This review critically evaluates recent progress in the development of antisense ODNs.

引用

页码：333 / 335

页数：3

共 53 条

[1]

ABE J, 1994, BIOCHEM BIOPH RES CO, V198, P116

[2] PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE [J].