MECHANISMS OF THE DEVELOPMENT OF TRAZODONE WITHDRAWAL SYMPTOMS

被引：14

作者：

OTANI, K

TANAKA, O

KANEKO, S

ISHIDA, M

YASUI, N

FUKUSHIMA, Y

机构：

[1] Department of Neuropsychiatry, Hirosaki University Hospital, Hirosaki

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1994年 / 9卷 / 02期

关键词：

M-CHLOROPHENYLPIPERAZINE; 1/2-LIFE; NORADRENALINE; SEROTONIN; TRAZODONE; WITHDRAWAL SYMPTOMS;

D O I：

10.1097/00004850-199400920-00011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Three cases developed withdrawal symptoms of trazodone despite gradual discontinuation of therapeutic doses of the drug. This report suggests that effects of trazodone and its metabolite m-chlorophenylpiperazine on the serotonergic system, which may result in noradrenergic rebound after discontinuation, and short half-lives of these compounds are involved in the development of these symptoms. From a clinical point of view, we suggest that trazodone should be tapered off at a very slow rate.

引用

页码：131 / 133

页数：3

共 17 条

[1]

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