ENDOTOXINS MODIFY MUSCLE FATIGUE CHARACTERISTICS

被引：10

作者：

GOUBEL, F ^{[1
]}

PIGOT, A ^{[1
]}

ALLAF, O ^{[1
]}

VERLEYE, M ^{[1
]}

GILLARDIN, JM ^{[1
]}

机构：

[1] ZAC MERCIERES,BIOCODEX LABS,F-60200 COMPIEGNE,FRANCE

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1995年 / 9卷 / 02期

关键词：

SKELETAL MUSCLE; MUSCLE FATIGUE; ENDOTOXINS; INFECTION;

D O I：

10.1111/j.1472-8206.1995.tb00282.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To test the hypothesis that endotoxins can directly modify muscle fatigue characteristics, in vitro experiments were performed on rat muscles 48 hours after injection of lipopolysaccharides (LPS) from Klebsiella pneumoniae. Resistance to fatigue was quantified by measuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. LPS treatment did not significantly modify initial force production whereas fatigability of the muscle was increased. This in vitro preparation should be used for testing antifatigue drugs.

引用

页码：202 / 204

页数：3

共 8 条

[1] PHYSIOLOGICAL TYPES AND HISTOCHEMICAL PROFILES IN MOTOR UNITS OF CAT GASTROCNEMIUS [J].