SOLUBLE FORM OF P-SELECTIN IN PLASMA IS ELEVATED IN ACUTE LUNG INJURY

被引：94

作者：

SAKAMAKI, F

ISHIZAKA, A

HANDA, M

FUJISHIMA, S

URANO, T

SAYAMA, K

NAKAMURA, H

KANAZAWA, M

KAWASHIRO, T

KATAYAMA, M

IKEDA, Y

机构：

[1] KEIO UNIV,SCH MED,DEPT MED,SHINJUKU KU,TOKYO 160,JAPAN

[2] KEIO UNIV,SCH MED,CTR BLOOD,SHINJUKU KU,TOKYO 160,JAPAN

[3] TAKARA SHUZO BIOTECHNOL RES LABS,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1995年 / 151卷 / 06期

关键词：

D O I：

10.1164/ajrccm.151.6.7539327

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI(n = 8) were also studied for comparison. PPS in patients with ALI (474.5 +/- 366.8 ng/ml, mean +/- SD) were significantly higher than those in control subjects (98.8 +/- 39.7, p < 0.01) and in patients with IPF(210.4 +/- 76.6, p < 0.05), sarcoidosis (135.2 +/- 71.5, p < 0.05) pneumonia (225.3 +/- 81.0, p < 0.05), and sepsis without ALI (271.8 +/- 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level(r = 0.605, p < 0.05). PPS levels of deceased patients with ALI(841.0 +/- 252.4) were significantly higher than those of surviving patients with Atl (208.0 +/- 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.

引用

页码：1821 / 1826

页数：6

共 31 条

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