Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance

被引：15

作者：

Elliott, KJ

Brodsky, M

Hynansky, A

Foley, KM

Inturrisi, CE

机构：

来源：

NEUROLOGY | 1995年 / 45卷 / 12期

关键词：

D O I：

10.1212/WNL.45.12_Suppl_8.S66

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The oral antitussive dextromethorphan is a clinically available N-methyl-D-aspartate receptor antagonist. Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models. These data suggest that dextromethorphan should be evaluated in a controlled clinical trial for analgesic efficacy in tester-associated neuralgia.

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页码：S66 / S68

页数：3

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