UROKINASE - STABILITY STUDIES IN SOLUTION AND LYOPHILIZED FORMULATIONS

被引：5

作者：

PATEL, JP

机构：

[1] Pharmaceutical Products Division, Abbott Laboratories, North Chicago, IL, 60064

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 18期

关键词：

D O I：

10.3109/03639049009058550

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Urokinase - a serine protease - is used clinically as a thrombolytic agent to dissolve blood clots. Low molecular weight Urokinase (33,000 dalton) isolated from human kidney cells using tissue culture techniques was used in the stability studies. Quantitative determination of Urokinase was accomplished by either amidolytic or fibrinolytic activity assay methods. The degradation of Urokinase in solution at 55-degrees-C follows pseudo-first order kinetics at several pH values. The pH range for maximum stability has been determined to be about 6 to 7.

引用

页码：2613 / 2626

页数：14

共 13 条

[1]

FINNEY DJ, 1964, STATISTICAL METHODS

[2]

FRITZ H, 1983, ARZNEIMITTELFORSCH, V33-1, P479

[3]

GAFFNEY PJ, 1981, THROMB HAEMOSTASIS, V45, P34

[4] THE PRIMARY STRUCTURE OF HIGH MOLECULAR MASS UROKINASE FROM HUMAN-URINE - THE COMPLETE AMINO-ACID-SEQUENCE OF THE A-CHAIN [J].