THE IMMUNE RECOGNITION OF MALARIA ANTIGENS

被引：39

作者：

RILEY, EM

OLERUP, O

TROYEBLOMBERG, M

机构：

[1] KAROLINSKA INST,NOVUM,CTR BIOTECHNOL,S-14186 HUDDINGE,SWEDEN

[2] UNIV STOCKHOLM,WENNER GREN INST,DEPT IMMUNOL,S-11345 STOCKHOLM,SWEDEN

来源：

PARASITOLOGY TODAY | 1991年 / 7卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0169-4758(91)90076-Z

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Owing to the demonstration that the immune response of inbred mice to some defined malaria antigens is influenced by the major histocompatibility complex (MHC), and the finding that only a minority of individuals living in malaria-endemic areas appear to recognize such antigens, there are fears that synthetic subunit malaria vaccines will be poorly immunogenic in a substantial proportion of the target population. Such fears have been reinforced by the results of the first two human malaria vaccine trials1,2. In this review Eleanor Riley, Olle Olerup and Marita Troye-Blomberg summarize the experimental evidence for MHC-related genetic restriction of malaria immunity and discuss some alternative explanations for nonresponsiveness in populations living in malaria-endemic areas.

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页码：5 / 11

页数：7

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