ALTERED EXPRESSION OF INSULIN-RECEPTOR TYPE-A AND TYPE-B IN THE SKELETAL-MUSCLE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS

被引：116

作者：

MOSTHAF, L ^{[1
]}

VOGT, B ^{[1
]}

HARING, HU ^{[1
]}

ULLRICH, A ^{[1
]}

机构：

[1] INST DIABET FORSCH MUNCHEN,W-8000 MUNICH 40,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 11期

关键词：

D O I：

10.1073/pnas.88.11.4728

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human insulin receptor exists in two isoforms, HIR-A and HIR-B, which are generated by alternative splicing of a primary gene transcript and differ by a 12-amino acid insertion sequence in the alpha-subunit. The two receptor isoforms bind insulin with different affinities and are differentially expressed in human tissues. We report here a tissue-specific alteration of the insulin receptor RNA splice pattern in non-insulin-dependent diabetes mellitus (NIDDM) patients. Whereas skeletal muscle of healthy individuals contains exclusively high-affinity HIR-A-encoding RNA, we consistently find low-affinity HIR-B RNA expression in NIDDM muscle tissue at levels similar to HIR-A.

引用

收藏

页码：4728 / 4730

页数：3

相关论文

共 32 条

[1] A MUTATION IN THE INSULIN-RECEPTOR GENE THAT IMPAIRS TRANSPORT OF THE RECEPTOR TO THE PLASMA-MEMBRANE AND CAUSES INSULIN-RESISTANT DIABETES [J].

ACCILI, D ;

FRAPIER, C ;

MOSTHAF, L ;

MCKEON, C ;

ELBEIN, SC ;

PERMUTT, MA ;

RAMOS, E ;

LANDER, E ;

ULLRICH, A ;

TAYLOR, SI .

EMBO JOURNAL, 1989, 8 (09) :2509-2517

[2] DEFECTIVE INSULIN-RECEPTOR TYROSINE KINASE IN HUMAN SKELETAL-MUSCLE IN OBESITY AND TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS [J].

ARNER, P ;

POLLARE, T ;

LITHELL, H ;

LIVINGSTON, JN .

DIABETOLOGIA, 1987, 30 (06) :437-440

[3] STUDIES ON THE MECHANISM OF INSULIN RESISTANCE IN THE LIVER FROM HUMANS WITH NONINSULIN-DEPENDENT DIABETES - INSULIN ACTION AND BINDING IN ISOLATED HEPATOCYTES, INSULIN-RECEPTOR STRUCTURE, AND KINASE-ACTIVITY [J].

CARO, JF ;

ITTOOP, O ;

PORIES, WJ ;

MEELHEIM, D ;

FLICKINGER, EG ;

THOMAS, F ;

JENQUIN, M ;

SILVERMAN, JF ;

KHAZANIE, PG ;

SINHA, MK .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (01) :249-258

[4] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[5]

DeFronzo R A, 1983, Am J Med, V74, P52, DOI 10.1016/0002-9343(83)90654-X

[6] THE HUMAN INSULIN-RECEPTOR CDNA - THE STRUCTURAL BASIS FOR HORMONE-ACTIVATED TRANSMEMBRANE SIGNALING [J].

EBINA, Y ;

ELLIS, L ;

JARNAGIN, K ;

EDERY, M ;

GRAF, L ;

CLAUSER, E ;

OU, JH ;

MASIARZ, F ;

KAN, YW ;

GOLDFINE, ID ;

ROTH, RA ;

RUTTER, WJ .

CELL, 1985, 40 (04) :747-758

[7] DECREASED KINASE-ACTIVITY OF INSULIN-RECEPTORS FROM ADIPOCYTES OF NON-INSULIN-DEPENDENT DIABETIC SUBJECTS [J].

FREIDENBERG, GR ;

HENRY, RR ;

KLEIN, HH ;

REICHART, DR ;

OLEFSKY, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :240-250

[8] 2 MUTANT ALLELES OF THE INSULIN-RECEPTOR GENE IN A PATIENT WITH EXTREME INSULIN RESISTANCE [J].

KADOWAKI, T ;

BEVINS, CL ;

CAMA, A ;

OJAMAA, K ;

MARCUSSAMUELS, B ;

KADOWAKI, H ;

BEITZ, L ;

MCKEON, C ;

TAYLOR, SI .

SCIENCE, 1988, 240 (4853) :787-790

[9] THE INSULIN-RECEPTOR AND THE MOLECULAR MECHANISM OF INSULIN ACTION [J].

KAHN, CR ;

WHITE, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (04) :1151-1156

[10] A LEUCINE-TO-PROLINE MUTATION IN THE INSULIN-RECEPTOR IN A FAMILY WITH INSULIN RESISTANCE [J].

KLINKHAMER, MP ;

GROEN, NA ;

VANDERZON, GCM ;

LINDHOUT, D ;

SANDKUYL, LA ;

KRANS, HMJ ;

MOLLER, W ;

MAASSEN, JA .

EMBO JOURNAL, 1989, 8 (09) :2503-2507

← 1 2 3 4 →