DETERMINATION OF PROLIFERATION INDEX IN ADVANCED OVARIAN-CANCER USING QUANTITATIVE IMAGE-ANALYSIS

被引:21
作者
JORDAN, PA
KERNS, BJM
PENCE, JC
KOHLER, MF
BAST, RC
KINNEY, RB
BERCHUCK, A
机构
[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,DEPT MICROBIOL IMMUNOL,DURHAM,NC 27710
[3] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710
[4] DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710
[5] DUKE UNIV,MED CTR,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC 27710
关键词
KI-67; OVARIAN CANCER; IMMUNOHISTOCHEMISTRY; IMAGE CYTOMETRY;
D O I
10.1093/ajcp/99.6.736
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
It has been shown that the monoclonal antibody Ki-67 reacts with a nuclear antigen that is expressed only by proliferating cells. The feasibility of using image analysis to quantitate Ki-67 staining (proliferation index [PI]) of epithelial ovarian cancers was investigated. The PI was determined in 50 advanced-stage primary ovarian cancers. Frozen sections were immunostained with the Ki-67 monoclonal antibody, and the PI was calculated using static image analysis. Among 35 stage III ovarian carcinomas, the median PI was 8.9%, compared with 17.7% in 15 stage IV cancers (P = 0.06). There was no relationship between PI and histologic grade. The median survival time of 32 patients whose cancers had a high Ki-67 expression (greater-than-or-equal-to 7.5%) was 16.8 months, which differed significantly (P<0.01) from the median survival of 31.5 months observed in patients whose tumors demonstrated low Ki-67 expression (<7.5%). Quantitative image analysis of Ki-67-stained fresh-frozen ovarian cancers may provide useful prognostic information. Further studies are warranted to investigate the relationship between Ki-67 expression and other known clinicopathologic and genetic features of ovarian cancer.
引用
收藏
页码:736 / 740
页数:5
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