COMPARATIVE ACTIVITY OF AMPICILLIN, AMOXICILLIN, AMOXYCILLIN/CLAVULANATE AND CEFOTAXIME AGAINST 189 PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT PNEUMOCOCCI

Agar dilution and E-test MICs of penicillin G, ampicillin, amoxycillin, amoxycillin/ clavulanate and cefotaxime were determined against 189 pneumococci. Addition of clavulanate did not influence amoxycillin MICs, MIC(50)/MIC(90) (mg/L) for penicillin G, ampicillin, amoxycillin and cefotaxime were: Penicillin susceptible strains (62): 0.03/0.03; 0.03/0.06; 0.015/0.03; 0.015/0.06. Penicillin intermediate strains (69): 0.25/1.0; 0.25/4.0; 0.125/1.0; 0.125/1.0. Penicillin resistant strains (58): 2.0/4.0; 4.0/4.0;1.0/2.0; 1.0/2.0. E-test MICs correlated well with those obtained by agar dilution.