Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical reductive alkylation strategy

被引：22

作者：

Blagbrough, IS

Moya, E

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy and Pharmacology, University of Bath, Bath, BA2 7AY, Claverton Down

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/0040-4039(95)01994-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin-636, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. Central to this synthesis are a Swern oxidation and a reductive alkylation.

引用

页码：9393 / 9396

页数：4

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