THE EFFECT OF SOMATIC MUTATION ON ANTIBODY-AFFINITY

被引：11

作者：

GEARHART, PJ

机构：

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 1983年 / 418卷 / DEC期

关键词：

D O I：

10.1111/j.1749-6632.1983.tb18064.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：171 / 176

页数：6

共 9 条

[1] A SINGLE VH GENE SEGMENT ENCODES THE IMMUNE-RESPONSE TO PHOSPHORYLCHOLINE - SOMATIC MUTATION IS CORRELATED WITH THE CLASS OF THE ANTIBODY [J].

CREWS, S ;

GRIFFIN, J ;

HUANG, H ;

CALAME, K ;

HOOD, L .

CELL, 1981, 25 (01) :59-66

[2] AN IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION GENE IS GENERATED FROM 3 SEGMENTS OF DNA - VH, D AND JH [J].

EARLY, P ;

HUANG, H ;

DAVIS, M ;

CALAME, K ;

HOOD, L .

CELL, 1980, 19 (04) :981-992

[3] CLUSTERS OF POINT MUTATIONS ARE FOUND EXCLUSIVELY AROUND REARRANGED ANTIBODY VARIABLE GENES [J].

GEARHART, PJ ;

BOGENHAGEN, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (11) :3439-3443

[4] IGG ANTIBODIES TO PHOSPHORYLCHOLINE EXHIBIT MORE DIVERSITY THAN THEIR IGM COUNTERPARTS [J].

GEARHART, PJ ;

JOHNSON, ND ;

DOUGLAS, R ;

HOOD, L .

NATURE, 1981, 291 (5810) :29-34

[5] SOMATIC DIVERSIFICATION IS REQUIRED TO GENERATE THE V-KAPPA GENES OF MOPC 511 AND MOPC 167 MYELOMA PROTEINS [J].

GERSHENFELD, HK ;

TSUKAMOTO, A ;

WEISSMAN, IL ;

JOHO, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7674-7678

[6] ANTIBODY DIVERSITY - SOMATIC HYPER-MUTATION OF REARRANGED VH GENES [J].

KIM, S ;

DAVIS, M ;

SINN, E ;

PATTEN, P ;

HOOD, L .

CELL, 1981, 27 (03) :573-581

[7] SEQUENCES OF 5 POTENTIAL RECOMBINATION SITES ENCODED CLOSE TO AN IMMUNOGLOBULIN K-CONSTANT REGION GENE [J].

MAX, EE ;

SEIDMAN, JG ;

LEDER, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) :3450-3454

[8]

RODWELL JD, 1983, J IMMUNOL, V130, P313

[9] SOMATIC MUTATION OF IMMUNOGLOBULIN LIGHT-CHAIN VARIABLE-REGION GENES [J].

SELSING, E ;

STORB, U .

CELL, 1981, 25 (01) :47-58

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