THE EFFECTS OF THAPSIGARGIN ON [CA2+](I) IN ISOLATED RAT MESENTERIC-ARTERY VASCULAR SMOOTH-MUSCLE CELLS

被引：42

作者：

BARO, I ^{[1
]}

EISNER, DA ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT VET PRECLIN SCI,POB 147,LIVERPOOL L69 3BX,ENGLAND

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1992年 / 420卷 / 01期

基金：

英国惠康基金;

关键词：

THAPSIGARGIN; INTRACELLULAR CALCIUM; SMOOTH MUSCLE CELL; NORADRENALINE; CAFFEINE;

D O I：

10.1007/BF00378652

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of thapsigargin were studied on single cells isolated from side branches of the rat mesenteric artery. Thapsigargin (150 nM) produced a transient increase of [Ca2+]i. This transient rise of [Ca2+]i was unaffected by removing external Ca2+ ions. This suggests that thapsigargin is releasing Ca2+ ions from an intracellular store. In the absence of thapsigargin both noradrenaline and caffeine also produced a transient increase of [Ca2+]i. These increases were abolished by prior exposure to thapsigargin. Correspondingly, the effects of thapsigargin were abolished by prior exposure to caffeine. These results show that thapsigargin releases Ca2+ from the noradrenaline and caffeine-sensitive stores.

引用

页码：115 / 117

页数：3

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