AGE-DEPENDENT DECLINE IN MOTOR EVOKED-POTENTIAL (MEP) AMPLITUDE - WITH A COMMENT ON CHANGES IN PARKINSONS-DISEASE

被引：71

作者：

EISEN, A ^{[1
]}

SIEJKA, S ^{[1
]}

SCHULZER, M ^{[1
]}

CALNE, D ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT MED NEUROL,VANCOUVER V6T 1W5,BC,CANADA

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1991年 / 81卷 / 03期

基金：

英国医学研究理事会;

关键词：

MOTOR EVOKED POTENTIAL; TRANSCRANIAL MAGNETIC STIMULATION; PARKINSONS DISEASE; AMPLITUDE; AGING;

D O I：

10.1016/0168-5597(91)90074-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Peak-to-peak measurement of the maximum amplitude motor evoked potential (MAXMEP) elicited by 20 consecutive transcranial magnetic stimuli recorded from the contracting thenar and hypothenar muscles measured 9.8 +/- 2.0 mV and 7.25 +/- 2.9 mV respectively (P < 0.01). The ratio of MAXMEP/CMAP measured 92.6 +/- 25.8% and 54.8 +/- 12.3% respectively (P < 0.001). Repeat studies showed good individual reproducibility. Amplitudes declined linearly with age (r = -0.836 for thenar MAXMEP P < 0.001). It is argued that MAXMEP related to age is more meaningful than the MEP/CMAP wave ratio and is proportional to the number of fast conducting cortical motor neurons excited. In 7/18 patients with Parkinson's disease (PD) MAXMEP was increased; in 2 other patients MAXMEP was decreased for their age.

引用

页码：209 / 215

页数：7

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