AGGREGATION PROPERTIES OF GD1B, II(3)NEU5AC2GGOSE4CER, AND OF GD1B-LACTONE, II(3)[ALPHA-NEU5AC-(2-]8, 1-]9)-ALPHA-NEU5AC]GGOSE4CER, IN AQUEOUS-SOLUTION

被引：23

作者：

CANTU, L ^{[1
]}

CORTI, M ^{[1
]}

CASELLATO, R ^{[1
]}

ACQUOTTI, D ^{[1
]}

SONNINO, S ^{[1
]}

机构：

[1] UNIV MILAN,SCH MED,DEPT MED CHEM & BIOCHEM,STUDY CTR FUNCT BIOCHEM,VIA SALDINI 50,I-20133 MILAN,ITALY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1991年 / 60卷 / 02期

关键词：

GANGLIOSIDES; GANGLIOSIDE LACTONES; GANGLIOSIDE AGGREGATES; LIGHT SCATTERING; PHASE SEPARATION;

D O I：

10.1016/0009-3084(91)90033-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relevance of the presence of an inner ester in the oligosaccharide chain on the aggregative properties of gangliosides is investigated. Micellar molecular weight and hydrodynamic radius of natural GD1b and of semisynthetic GD1b-lactone are measured by the laser light scattering technique. The presence of the lactone ring causes an increase of 36% for the molecular weight and 16% for the hydrodynamic radius. Measurements on mixtures of GD1b and GD1b-lactone show that mixed micelles are formed with microdomain structure. The results are interpreted in terms of the geometrical packing model for the aggregation of amphiphilic molecules and are correlated to membrane processes.

引用

页码：111 / 118

页数：8

共 39 条

[1] GANGLIOSIDE LACTONES - H-1-NMR DETERMINATION OF THE INNER ESTER POSITION OF GD1B-GANGLIOSIDE LACTONE NATURALLY-OCCURRING IN HUMAN-BRAIN OR PRODUCED BY CHEMICAL SYNTHESIS [J].