DIETARY-REGULATION OF GLUCOSE-TRANSPORTER GENE-EXPRESSION - TISSUE-SPECIFIC EFFECTS IN ADIPOSE-CELLS AND MUSCLE

被引:51
作者
KAHN, BB [1 ]
机构
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02215 USA
关键词
DIETARY FAT; FASTING; MUSCLE; GLUCOSE TRANSPORTER; GENE EXPRESSION; ADIPOSE TISSUE;
D O I
10.1093/jn/124.suppl_8.1289S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The rapid stimulation of glucose transport into the classic insulin responsive tissues, muscle and adipose cells, is crucial for maintenance of glucose homeostasis in the fed state. Macronutrient content and composition of the diet strongly influence glucose transport into these tissues by altering both the expression of the glucose transporter genes (GLUT1 and GLUT4) and the functional activity of the gene products. Dietary regulation of GLUT1 and GLUT4 is tissue specific. With high fat feeding alterations in transporter expression is much greater in adipose cells than in skeletal muscle. In the unfed state there is a profound down regulation of glucose transporter gene expression in adipose cells while expression of the same transporter genes is increased in skeletal muscle, Thus, tissue specific regulation of glucose transporter expression and function appears to be part of the adaptive response to maintain adequate cellular nutrition in times of altered nutrient availability.
引用
收藏
页码:S1289 / S1295
页数:7
相关论文
共 23 条
[1]   MOLECULAR-BIOLOGY OF MAMMALIAN GLUCOSE TRANSPORTERS [J].
BELL, GI ;
KAYANO, T ;
BUSE, JB ;
BURANT, CF ;
TAKEDA, J ;
LIN, D ;
FUKUMOTO, H ;
SEINO, S .
DIABETES CARE, 1990, 13 (03) :198-208
[2]  
BURANT CF, 1991, RECENT PROG HORM RES, V47, P349
[3]  
CHARRON MJ, 1990, J BIOL CHEM, V265, P7994
[4]   INSULIN-RESPONSE IN SKELETAL-MUSCLE AND FAT-CELLS OF GENETICALLY OBESE ZUCKER RAT [J].
CZECH, MP ;
RICHARDSON, DK ;
BECKER, SG ;
WALTERS, CG ;
GITOMER, W ;
HEINRICH, J .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1978, 27 (12) :1967-1981
[5]   THE EFFECT OF INSULIN ON THE DISPOSAL OF INTRAVENOUS GLUCOSE - RESULTS FROM INDIRECT CALORIMETRY AND HEPATIC AND FEMORAL VENOUS CATHETERIZATION [J].
DEFRONZO, RA ;
JACOT, E ;
JEQUIER, E ;
MAEDER, E ;
WAHREN, J ;
FELBER, JP .
DIABETES, 1981, 30 (12) :1000-1007
[6]   DECREASED INSULIN BINDING, GLUCOSE-TRANSPORT, AND GLUCOSE-METABOLISM IN SOLEUS MUSCLE OF RATS FED A HIGH-FAT DIET [J].
GRUNDLEGER, ML ;
THENEN, SW .
DIABETES, 1982, 31 (03) :232-237
[7]  
HOLMAN GD, 1990, J BIOL CHEM, V265, P18172
[8]   SUPPRESSION OF GLUT4 EXPRESSION IN SKELETAL-MUSCLE OF RATS THAT ARE OBESE FROM HIGH-FAT FEEDING BUT NOT FROM HIGH-CARBOHYDRATE FEEDING OR GENETIC OBESITY [J].
KAHN, BB ;
PEDERSEN, O .
ENDOCRINOLOGY, 1993, 132 (01) :13-22
[9]   FACILITATIVE GLUCOSE TRANSPORTERS - REGULATORY MECHANISMS AND DYSREGULATION IN DIABETES [J].
KAHN, BB .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (05) :1367-1374
[10]   DIVERGENT MECHANISMS FOR THE INSULIN RESISTANT AND HYPERRESPONSIVE GLUCOSE-TRANSPORT IN ADIPOSE-CELLS FROM FASTED AND REFED RATS - ALTERATIONS IN BOTH GLUCOSE TRANSPORTER NUMBER AND INTRINSIC ACTIVITY [J].
KAHN, BB ;
SIMPSON, IA ;
CUSHMAN, SW .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :691-699