KININASE ACTIVITY IN HUMAN BLOOD IN NORMAL AND PATHOLOGICAL CONDITIONS

Kininase activity in blood was estimated in 17 healthy subjects and 162 patients with various diseases. The assay method consists of the incubation of synthetic bradykinin with venous blood at 37[degree]C for 10 min. and the quantitation of remaining bradykinin with guinea-pig ileum. In healthy subjects, kininase activities were 53-72% with the mean of 64. 4%. High activities were observed in patients with hyperthyroidism and in those with liver diseases. In patients with bronchial asthma, relatively low activities were found. No significant changes in the activity were found in other diseases.