INFLUENCE OF PEFLOXACIN ON MICROBIAL COLONIZATION RESISTANCE IN HEALTHY-VOLUNTEERS

被引：7

作者：

VOLLAARD, EJ ^{[1
]}

CLASENER, HAL ^{[1
]}

JANSSEN, AJHM ^{[1
]}

机构：

[1] CANISUS WILHELMINA HOSP,DEPT MICROBIOL,6532 S2 NIJMEGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1992年 / 11卷 / 03期

关键词：

D O I：

10.1007/BF02098093

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The influence of pefloxacin, 400 mg twice daily for ten days, on microbial colonization resistance was investigated in six healthy volunteers. In three volunteers impairment of colonization resistance was indicated by a significant increase in the faecal concentration of yeasts. In two of them, impairment of colonization resistance was confirmed by facilitation of colonization by a challenge strain of Klebsiella pneumoniae in the early post-treatment period. It is concluded that pefloxacin impairs colonization resistance in some volunteers. However, during pefloxacin therapy, overgrowth by aerobic bacteria is prevented by the very high antimicrobial concentration in faeces, and after therapy it is prevented by rapid restoration of colonization resistance.

引用

页码：257 / 260

页数：4

共 11 条

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