SURFACE ANTIMICROBIAL ACTIVITY OF HEPARIN-BONDED AND ANTISEPTIC-IMPREGNATED VASCULAR CATHETERS

被引:81
作者
MERMEL, LA
STOLZ, SM
MAKI, DG
机构
[1] BROWN UNIV,SCH MED,PROVIDENCE,RI 02912
[2] UNIV WISCONSIN,SCH MED,DEPT MED,INFECT DIS SECT,MADISON,WI 53706
关键词
D O I
10.1093/infdis/167.4.920
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Most Swan-Ganz pulmonary artery catheters have heparin bonded to the surface with benzalkonium chloride, a cationic surfactant, to reduce thrombosis. Since benzalkonium is bactericidal, the antimicrobial activity of heparin-bonded pulmonary artery catheters was investigated in an in vitro assay. Each catheter exhibited activity against a wide variety of potential microbial pathogens, including Candida albicans. The magnitude of activity against individual organisms correlated strongly with their in vitro susceptibility to benzalkonium chloride (r = .94, P < .002). A chlorhexidine-silver sulfadiazine-impregnated catheter exhibited even greater activity than the heparin-bonded catheters (P = .01). When exposed to serum for 24 h, heparin-bonded catheters lost greater-than-or-equal-to 50% of their antimicrobial activity, whereas the activity of the chlorhexidine-silver sulfadiazine-impregnated catheter was minimally affected. The fortuitous surface antimicrobial activity of heparin-bonded catheters may account for the low incidence of catheter-related bacteremia (mean, 1.0%) compared with Swan-Ganz catheters of the same materials but not coated with benzalkonium-heparin (mean, 2.8%).
引用
收藏
页码:920 / 924
页数:5
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