COPPER(II) INTERACTION AND COMPLEXATION WITH 1-[2(S)-3-MERCAPTO-3-METHYLPROPIONYL]-L-PROLINE (CAPTOPRIL)

被引：39

作者：

BONTCHEV, PR ^{[1
]}

GOCHEV, G ^{[1
]}

EVTIMOVA, B ^{[1
]}

KADUM, H ^{[1
]}

NACHEV, C ^{[1
]}

机构：

[1] ACAD MED SOFIA,CARDIOL CLIN,SOFIA,BULGARIA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 46卷 / 01期

关键词：

D O I：

10.1016/0162-0134(92)80060-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The redox processes between copper(II) and captopril, H2L, in a molar ratio 1:2 were studied. Copper(II) is reduced to Cu(I), which forms with the excess of captopril, a yellow complex, reoxidized by oxygen to a green complex Cu(II)L.H2O. The latter is studied using spectral (UV-Vis, IR), magnetochemical, EPR, DTA, and TGA methods. The coordination sites of the ligand are COO-, C = O, and S-. In a solid state the complex exists mainly as a dimer, the bridging realized by the carboxylate group of the ligand. The complex is soluble in pyridine, forming the mononuclear adduct CuCapt(py)3.

引用

页码：23 / 34

页数：12

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