ISOLATION AND PRIMARY STRUCTURE OF UROTENSIN-II FROM THE BRAIN OF A TETRAPOD, THE FROG RANA-RIDIBUNDA

被引：94

作者：

CONLON, JM ^{[1
]}

OHARTE, F ^{[1
]}

SMITH, DD ^{[1
]}

TONON, MC ^{[1
]}

VAUDRY, H ^{[1
]}

机构：

[1] UNIV ROUEN HAUTE NORMANDIE,EUROPEAN INST PEPTIDE RES,MOLEC ENDOCRINOL LAB,CNRS,URA 650,INSERM,F-76134 MONT ST AIGNAN,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91095-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A peptide related to urotensin II has been isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the peptide was established as Ala-Gly-Asn-Leu-Ser-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Val and this sequence was confirmed by chemical synthesis. Frog urotensin II contains an additional amino acid residue compared with fish urotensin II peptides but the structure of the cyclic region of the molecule has been fully conserved. The data show that urotensin II is not confined to the caudal neurosecretory system of fish but is present in the central nervous system of a tetrapod. © 1992.

引用

页码：578 / 583

页数：6

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