SULFOBACIN-A AND SULFOBACIN-B, NOVEL VON-WILLEBRAND-FACTOR RECEPTOR ANTAGONISTS .1. PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES

被引：40

作者：

KAMIYAMA, T

UMINO, T

SATOH, T

SAWAIRI, S

SHIRANE, M

OHSHIMA, S

YOKOSE, K

机构：

[1] Nippon Roche Research Center, Kamakura 247

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 09期

关键词：

D O I：

10.7164/antibiotics.48.924

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sulfobacins A and B, novel von Willebrand factor (vWF) receptor antagonists, have been isolated from the culture broth of Chryseobacterium so. (Flavobacterium sp.)dagger NR 2993 by ethyl acetate extraction, and by Sephadex LH-20 and silica gel column chromatographies. The physico-chemical properties of the sulfobacins indicate that their structures are completely different from that of aurintricarboxylic acid, the one known VWF receptor antagonist. Sulfobacins A and B inhibit the binding of VWF to its receptor with IC(50)s of 0.47 and 2.2 mu M, respectively. Sulfobacin A also inhibits ristocetin-induced agglutination in human platelets fixed with paraformaldehyde with an IC50 of 0.58 mu M.

引用

页码：924 / 928

页数：5

共 9 条

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