CIRCADIAN-RHYTHMS AND CANCER-CHEMOTHERAPY

被引：44

作者：

FOCAN, C ^{[1
]}

机构：

[1] CTR HOSP ST JOSEPH ESPERANCE, DEPT ONCOL, B-4000 LIEGE, BELGIUM

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 67卷 / 01期

关键词：

CIRCADIAN RHYTHMS; CANCER; ANIMALS; HUMANS; CHEMOTHERAPY; CHRONOTHERAPY;

D O I：

10.1016/0163-7258(95)00009-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Experimental and clinical pertinent data regarding circadian rhythmicities are reviewed in (1) target tissues, i.e., healthy tissues (actively proliferating or not) and tumor tissues, (2) pharmacology of anticancer agents, (3) toxicity and tolerance of these agents and (4) antitumor activity of cancer chemotherapy. The basic concepts of chronotolerance and/or of chronoefficacy have brought new hopes for further amelioration in the management of cancer patients. Quite recent published Phase II and III clinical trials have demonstrated that new improvements on the therapeutic index have been achieved through ambulatory chronotherapy for various solid tumors.

引用

页码：1 / 52

页数：52

共 289 条

[1] PERSISTENCE OF A CIRCADIAN RHYTHMICITY OF GLUCOCORTICOID SECRETION IN A PATIENT WITH CUSHINGS-SYNDROME - STUDY BEFORE AND AFTER UNILATERAL ADRENALECTOMY [J].

AMBROSI, B ;

RIVA, E ;

FAGLIA, G .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1985, 8 (04) :363-372

[2]

BADRAN AF, 1965, J NATL CANCER I, V35, P285

[3] PERIODIC HORMONOGENESIS - NEW PHENOMENON - PERIODICITY IN FUNCTION OF A HORMONE-PRODUCING TUMOR IN MAN [J].

BAILEY, RE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1971, 32 (03) :317-+

[4]

BAILLEUL F, 1986, Chronobiology International, V3, P47, DOI 10.3109/07420528609083159

[5]

BAILLEUL F, 1987, CHRONOBIOLOGIA, P150

[6]

BARBASON H, 1985, THESIS U LIEGE

[7]

BARBASON HR, 1970, CR ACAD SCI D NAT, V270, P3295

[8]

BARBIROLI B, 1972, CANCER RES, V32, P7

[9]

BASERGA R, 1971, CELL CYCLE CANCER

[10]

BELANGER PM, 1985, DRUG METAB DISPOS, V13, P386

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