Schizophrenic auditory hallucinations are associated with increased regional cerebral blood flow during verbal memory activation in a study using single photon emission computed tomography

被引：23

作者：

Busatto, GF ^{[1
]}

David, AS ^{[1
]}

Costa, DC ^{[1
]}

Ell, PJ ^{[1
]}

Pilowsky, LS ^{[1
]}

Lucey, JV ^{[1
]}

Kerwin, RW ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED, INST NUCL MED, LONDON, ENGLAND

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1995年 / 61卷 / 04期

基金：

英国惠康基金;

关键词：

cognition; basal ganglia; laterality;

D O I：

10.1016/0925-4927(95)02750-R

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Single photon emission tomography with split-dose technetium-99m-d,1-hexamethyl-propylene amine oxime was used to measure regional cerebral blood flow (rCBF) during a memory-activation paradigm in a group of 18 medicated DSM-III-R schizophrenic patients. The relationship between clinical features of schizophrenia and rCBF patterns was examined. Increased blood flow to the left basal ganglia was revealed during activation in patients reporting hallucinations in the previous month, a finding that was not influenced by medication dose or other confounding variables. This result adds to previous functional imaging studies that have related basal ganglia abnormalities to hallucinatory phenomena and suggests that left basal ganglia hyperactivity may be relevant to an internal monitoring deficit responsible for the appearance of those symptoms in schizophrenia.

引用

页码：255 / 264

页数：10

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