PH-RESPONSIVE RELEASE OF FLUOROPHORE FROM HOMOCYSTEINE-CARRYING POLYMERIZED LIPOSOMES

被引：19

作者：

KITANO, H

WOLF, H

ISE, N

机构：

[1] Department of Polymer Chemistry, Kyoto University, Kyoto

来源：

MACROMOLECULES | 1990年 / 23卷 / 07期

关键词：

D O I：

10.1021/ma00209a013

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polymerized liposomes consisting of anionic and neutral polymerizable lipids and N-meth- acryloly-D,L-homocysteine thiolactone (MHT) were prepared. The liposomes clearly showed a pH-dependent release of fluorescent dye from the inner water pool to the bulk phase. In contrast, when methacrylic acid was introduced instead of MHT, the polymerized liposome obtained showed no pH-dependent release. The homocysteine-containing polymerized liposomes might be useful as a device for a pH-responsive drug delivery system. © 1990, American Chemical Society. All rights reserved.

引用

页码：1958 / 1961

页数：4

共 15 条

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