EXPRESSION OF GATA-BINDING PROTEINS DURING EMBRYONIC-DEVELOPMENT IN XENOPUS-LAEVIS

被引:168
作者
ZON, LI
MATHER, C
BURGESS, S
BOLCE, ME
HARLAND, RM
ORKIN, SH
机构
[1] HOWARD HUGHES MED INST,BOSTON,MA 02115
[2] DEPT MOLEC & CELL BIOL,DIV BIOCHEM & MOLEC BIOL,BERKELEY,CA 94720
关键词
HEMATOPOIESIS; MESODERM; TRANSCRIPTION FACTOR; ERYTHROCYTES; ZINC-FINGER DOMAINS;
D O I
10.1073/pnas.88.23.10642
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Proteins that recognize the core sequence GATA are important regulators of hematopoietic-specific gene transcription. We have characterized cDNAs encoding the Xenopus laevis homologues of three related transcription factors, designated GATA-1, -2, and -3. Comparative sequence analysis reveals strong conservation of the zinc-ringer DNA-binding domain among all vertebrate GATA-binding proteins. GATA-2 and GATA-3 polypeptides are homologous throughout their entire sequences, whereas GATA-1 sequence is conserved only in the region responsible for DNA binding. In Xenopus, RNAs encoding GATA-binding proteins are expressed in both larval and adult erythroid cells. GATA-1, -2, and -3 RNAs are first detectable in early gastrula (Nieuwkoop developmental stage 11). This is earlier than the appearance of the early larval alpha-T1 globin RNA (stage 15), beta-T1 globin RNA (stage 26), or blood island formation (stage 30). The expression of GATA-1, -2, and -3 in early development may signal an early commitment of mesoderm to form hematopoietic tissue.
引用
收藏
页码:10642 / 10646
页数:5
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