EVALUATION OF A MONOCLONAL-ANTIBODY, BC-1, WHICH IDENTIFIES AN ANTIGEN EXPRESSED ON THE SURFACE-MEMBRANE OF HUMAN EXTRAVILLOUS TROPHOBLAST

被引：27

作者：

LOKE, YW

HSI, BL

BULMER, JN

GRIVAUX, C

HAWLEY, S

GARDNER, L

KING, A

CARTER, NP

机构：

[1] FAC MED NICE,IMMUNOL LAB,INSERM,U210,F-06034 NICE,FRANCE

[2] UNIV LEEDS,DEPT PATHOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1992年 / 27卷 / 1-2期

关键词：

MONOCLONAL ANTIBODY BC-1; TROPHOBLAST;

D O I：

10.1111/j.1600-0897.1992.tb00727.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper describes a new Mab BC-1 which is directed at a cell surface antigen expressed by extravillous cytotrophoblast and not by vinous cytotrophoblast, so it is useful for distinguishing between the two populations. The antigen recognised by BC-1 is trypsin-resistant, which allows it to be used for flow cytometric analysis of living trophoblast isolated by enzymic disaggregation. However, BC-1 is not trophoblast-specific but cross-reacts with some other tissues, in particular endothelial cells and peripheral blood monocytes. The nature of this antigen has not been established.

引用

页码：77 / 81

页数：5

共 6 条

[1] MONOCLONAL-ANTIBODIES TO HUMAN TROPHOBLAST AND SPERM ANTIGENS - REPORT OF 2 WHO-SPONSORED WORKSHOPS, JUNE 30, 1986 - TORONTO, CANADA [J].