ORAL-ADMINISTRATION OF ZINC DEUTEROPORPHYRIN IX 2,4 BIS GLYCOL INHIBITS HEME OXYGENASE IN NEONATAL RATS

被引：9

作者：

VALLIER, HA ^{[1
]}

RODGERS, PA ^{[1
]}

STEVENSON, DK ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PEDIAT,STANFORD,CA 94305

来源：

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1991年 / 17卷 / 3-4期

关键词：

HEME OXYGENASE; METALLOPORPHYRIN; ZINC DEUTEROPORPHYRIN IX 2,4 BIS GLYCOL; BILIRUBIN; NEONATAL JAUNDICE; ENTERAL ABSORPTION;

D O I：

10.1159/000457526

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zinc deuteroporphyrin IX 2,4 bis glycol (ZnBG) has been shown to be a potent inhibitor of heme oxygenase (HO) in vitro. Oral administration, which has been minimally effective with other metalloporphyrins, could be clinically advantageous for prevention of neonatal hyperbilirubinemia. Therefore, we examined the effect of oral administration of ZnBG on tissue HO activity and tissue ZnBG concentrations. Suckling rats at 2 weeks of age received ZnBG at 40-mu-mol/kg BW via gastric gavage. Rats were killed with anesthetic overdose after 60 min. ZnBG was detected in the portal and systemic circulation (n = 12), and the liver, kidney, spleen, and intestine (n = 8). ZnBG concentrations of 7.9 nmol/g liver and 1.7 nmol/g spleen corresponded to 67 and 72% inhibition of control HO activity (n = 9; p < 0.0005) respectively.

引用

页码：220 / 222

页数：3

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