HUMAN MONOCYTES/MACROPHAGES - NO OR NO NO

被引：265

作者：

DENIS, M ^{[1
]}

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT ANAT & CELL BIOL,SHERBROOKE J1H 5N4,PQ,CANADA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 55卷 / 05期

关键词：

NITRIC OXIDE; MONOCYTES/MACROPHAGES; INDUCIBLE NO SYNTHASE;

D O I：

10.1002/jlb.55.5.682

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The production of nitric oxide (NO) and other reactive nitrogen intermediates by cytokine-activated rodent cells is an important component of antimicrobial and/or antineoplasic activity of these cells. This pathway involves the oxidation of arginine to citrulline, with the concomitant release of NO by an inducible form of NO synthase (iNOS). Numerous cell types express iNOS after stimulation with bacterial products and/or cytokines. The role of NO and its derivatives in host resistance is a subject of intense investigation in mouse models of infections or neoplasia. Although human cells such as hepatocytes and endothelial cells have been shown to express an inducible NO synthase, the presence of such a pathway in human monocytes/macrophages has been questioned by many investigators and is a subject of great controversy. In this short review, we discuss some salient points of this debate.

引用

页码：682 / 684

页数：3

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