MACROCYCLIC POLYAMINOCARBOXYLATE COMPLEXES OF IANTHANIDES AS MAGNETIC-RESONANCE-IMAGING CONTRAST AGENTS

被引：130

作者：

KUMAR, K

TWEEDLE, MF

机构：

[1] Contrast Media Research Department, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ, 08903

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 03期

关键词：

D O I：

10.1351/pac199365030515

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrocyclic aminocarboxylates form thermodynamically stable and kinetically inert complexes of lanthanides e.g. Gd3+, which are clinically useful as MRI contrast agents. Solubility, relaxivity, thermodynamics and kinetics, crystal structure, and tolerance studies are presented here.

引用

页码：515 / 520

页数：6

共 22 条

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