A TRANSIENT MATHEMATICAL-MODEL OF OXYGEN DEPLETION DURING PHOTODYNAMIC THERAPY

被引：51

作者：

HENNING, JP ^{[1
]}

FOURNIER, RL ^{[1
]}

HAMPTON, JA ^{[1
]}

机构：

[1] MED COLL OHIO,DEPT PATHOL & UROL,TOLEDO,OH 43614

来源：

RADIATION RESEARCH | 1995年 / 142卷 / 02期

关键词：

D O I：

10.2307/3579032

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A transient one-dimensional mathematical model is presented to help visualize the qualitative and quantitative effects on intercapillary tissue undergoing photodynamic therapy (PDT). The model is solved by a Crank-Nicholson finite difference formulation to provide time-dependent concentrations of the Type II mechanism's photo-oxidation species in the tissue surrounding a capillary, The time-dependent solution allows educated decisions to be made as to the optimum timing of light fractionation (on/off) cycles, Qualitative and quantitative optimization of the PDT process is considered along with a case study of data in the literature, the main goal being to provide optimized light therapy regimens for eventual clinical use. (C) 1995 by Radiation Research Society

引用

页码：221 / 226

页数：6

共 20 条

[1]

AKAI TJ, 1994, APLIED NUMERICAL MET

[2]

BARLTROP JA, 1978, PRINCIPLES PHOTOCHEM, P1117

[3]

BIRD RB, 1960, TRANSPORT PHENOMENA, P554

[4] REGULATION OF VO2 IN RED MUSCLE - DO CURRENT BIOCHEMICAL HYPOTHESES FIT INVIVO DATA [J].