REACTIVE OXYGEN SPECIES PRODUCED FROM CHROMATE PIGMENTS AND ASCORBATE

被引：8

作者：

LEFEBVRE, Y ^{[1
]}

PEZERAT, H ^{[1
]}

机构：

[1] UNIV PARIS 06,REACT SURFACE & STRUCT LAB,F-75252 PARIS 05,FRANCE

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1994年 / 102卷

关键词：

CHROMATE; ASCORBATE; REACTIVE OXYGEN SPECIES; CHROMIUM(V); ELECTRON PARAMAGNETIC RESONANCE; CARCINOGENESIS;

D O I：

10.2307/3431794

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The reactions of various chromate pigments and ascorbate were investigated by an ESR spin trapping technique. Production of Cr(V) was detected directly acid productions of very electrophilic reactive oxygen species (ROS) was detected via the oxidation of formate. We demonstrated previously that both dissolved oxygen and Cr (V) were essential in the production of ROS in this system, and that ROS production was inhibited by catalase. We studied here the effect of solubility of different chromate pigments: sodium, calcium, strontium, basic zinc, basic lead supported on silica and lead and barium chromates on the production of ROS in buffered medium and cell culture medium (Dublecco's Modified Eagle medium + fetal calf serum). Sodium, calcium, basic zinc, and basic lead chromates were active in the production of ROS in presence of cell culture medium, whereas lead and barium chromates were inactive.

引用

页码：243 / 245

页数：3

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