Clinical role of bisphosphonate therapy

被引：23

作者：

Hampson, Geeta ^{[1
,2
]}

Fogelman, Ignac ^{[1
,3
]}

机构：

[1] Guys Hosp, Osteoporosis Screening Unit, London, England

[2] St Thomas Hosp, Dept Chem Pathol, 5th Floor,North Wing,Lambeth Palace Rd, London SE1 7EH, England

[3] Guys Hosp, Dept Nucl Med, London, England

来源：

INTERNATIONAL JOURNAL OF WOMENS HEALTH | 2012年 / 4卷

关键词：

pyrophosphate; bone resorption; postmenopausal osteoporosis; glucocorticoidinduced osteoporosis; Paget's disease of bone; malignancy-related bone loss;

D O I：

10.2147/IJWH.S24783

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Bisphosphonates (BPs) are synthetic analogues of pyrophosphate. They inhibit bone resorption and are therefore widely used in disorders where there are increases or disruptions in bone resorption. This includes postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, Paget's disease of bone, and malignancy-related bone loss. To best understand the clinical application of BPs, an understanding of their pharmacokinetics and pharmacodynamics is important. This review describes the structure, pharmacology and mode of action of BPs, focusing on their role in clinical practice. Controversies and side effects surrounding their use will also be discussed.

引用

页码：455 / 469

页数：15

共 88 条

[1]

Guidance on the use of bisphosphonates in solid tumours:: recommendations of an international expert panel [J].

Aapro, M. ;

Abrahamsson, P. A. ;

Body, J. J. ;

Coleman, R. E. ;

Colomer, R. ;

Costa, L. ;

Crino, L. ;

Dirix, L. ;

Gnant, M. ;

Gralow, J. ;

Hadji, P. ;

Hortobagyi, G. N. ;

Jonat, W. ;

Lipton, A. ;

Monnier, A. ;

Paterson, A. H. G. ;

Rizzoli, R. ;

Saad, F. ;

Thuerlimann, B. .

ANNALS OF ONCOLOGY, 2008, 19 (03) :420-432

[2]

Adachi JD, 2001, ARTHRITIS RHEUM, V44, P202, DOI 10.1002/1529-0131(200101)44:1<202::AID-ANR27>3.0.CO

[3]

2-W

[4]

AMIN D, 1992, J LIPID RES, V33, P1657

[5]

Berenson James R, 2011, Curr Opin Support Palliat Care, V5, P233, DOI 10.1097/SPC.0b013e328349dc17

[6]

Berry Scott, 2006, Can J Urol, V13, P3180

[7]

Serum 25-Hydroxyvitamin D Levels Modulate the Acute-Phase Response Associated With the First Nitrogen-Containing Bisphosphonate Infusion [J].

Bertoldo, Francesco ;

Pancheri, Serena ;

Zenari, Sonia ;

Boldini, Stefania ;

Giovanazzi, Benedetta ;

Zanatta, Mirko ;

Valenti, Maria Teresa ;

Carbonare, Luca Dalle ;

Lo Cascio, Vincenzo .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (03) :447-454

[8]

Guidelines for the diagnosis and management of multiple myeloma 2011 [J].

Bird, Jennifer M. ;

Owen, Roger G. ;

D'Sa, Shirley ;

Snowden, John A. ;

Pratt, Guy ;

Ashcroft, John ;

Yong, Kwee ;

Cook, Gordon ;

Feyler, Sylvia ;

Davies, Faith ;

Morgan, Gareth ;

Cavenagh, Jamie ;

Low, Eric ;

Behrens, Judith .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 154 (01) :32-75

[9]

Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis [J].

Black, Dennis M. ;

Delmas, Pierre D. ;

Eastell, Richard ;

Reid, Ian R. ;

Boonen, Steven ;

Cauley, Jane A. ;

Cosman, Felicia ;

Lakatos, Peter ;

Leung, Ping Chung ;

Man, Zulema ;

Mautalen, Carlos ;

Mesenbrink, Peter ;

Hu, Huilin ;

Caminis, John ;

Tong, Karen ;

Rosario-Jansen, Theresa ;

Krasnow, Joel ;

Hue, Trisha F. ;

Sellmeyer, Deborah ;

Eriksen, Erik Fink ;

Cummings, Steven R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (18) :1809-1822

[10]

The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT) [J].

Black, Dennis M. ;

Reid, Ian R. ;

Boonen, Steven ;

Bucci-Rechtweg, Christina ;

Cauley, Jane A. ;

Cosman, Felicia ;

Cummings, Steven R. ;

Hue, Trisha F. ;

Lippuner, Kurt ;

Lakatos, Peter ;

Leung, Ping Chung ;

Man, Zulema ;

Martinez, Ruvie Lou Maria ;

Tan, Monique ;

Ruzycky, Mary Ellen ;

Su, Guoqin ;

Eastell, Richard .

JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (02) :243-254

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